Levitra vardenafil is a medication used to treat erectile dysfunction (ED) in men. Levitra increases blood flow to the penis to help a man get and keep an erection. It works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5). Levitra can interact with other medications, particularly nitrates (often prescribed for chest pain), alpha-blockers (for high blood pressure or prostate problems), and certain other medications.