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Get UP to 20% Discount* on All Medicines. Use Coupon Code "FREE20" Check Details On Payment Page. Tramadol is a prescription medication that is used to relieve moderate to moderately severe pain. It is a synthetic opioid analgesic, which means it acts on the opioid receptors in the brain and changes how the body perceives and responds to pain. Tramadol is often prescribed when other pain medications are not effective or when a less potent opioid is desired.