When an opioid is taken into the body by any route (by mouth, nasally, smoking or injecting) it enters the blood stream and travels to the brain. When it attaches to an opioid receptor in the brain, our perception of pain is reduced (if we have pain) and we feel sedated. Most people also feel at least a mild pleasurable sensation, or a sense of well-being when opioid receptors are stimulated. Some report feeling more energized or motivated after taking opioids. A few experience unpleasant side effects such as nausea, vomiting or irritability. Unfortunately, those who are prone to develop an opioid addiction seem to experience an intense euphoric or pleasurable feeling when they take an opioid - leading to prolonged dependence requiring opioid addiction treatment.

An opioid seems to do something for their mood that it does not do for most people. Their experience with an opioid is quite different than it is for the person who is not prone to develop an opioid addiction. Drugs of abuse (like opioids, cocaine and alcohol) are addictive for the susceptible person because repeated use of those substances--in an effort to reproduce that intense euphoric feeling--results in long-term changes in the structure and the function of the brain. These changes in the brain start to drive their behavior, and when someone is suffering from opioid addiction, they want the drug even when the drug no longer provides pleasure.

Opioids that can be snorted, inhaled or injected reach the brain in a high concentration rapidly and result in an even more intense high, or a "rush". As a result, drugs that can be abused by these routes are often more appealing to the person seeking euphoria, and are therefore more addictive for the susceptible person.
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