Picture Prognosis Library

April 21, 2025

A 17-year-old female presents with a progressively enlarging abdominal distention over 4 months, causing shortness of breath when lying down. She is pale, dehydrated, and has prominent abdominal veins. Ultrasound shows a cystic, lobulated mass originating from the right ovary. What's Your Diagnosis?

April 14, 2025

A 30-year-old Asian male presents with a seven-year history of recurrent eye redness and blurred vision, now progressing to darkening and bulging of the sclera in both eyes. Examination reveals bilateral auricular deformities with mixed hearing loss and scleromalacia perforans. Laboratory tests show elevated inflammatory markers (CRP & ESR), negative ANA & RF, and no history of ocular trauma or surgery. What's Your Diagnosis?

April 07, 2025

A 48-year-old woman presents with a two-week history of unexplained persistent fever and arthralgias along with a two-month history of unintentional 20-pound weight loss. Imaging reveals multiple splenic infarcts and retroperitoneal/inguinal lymphadenopathy. Lymph node biopsy confirms histiocytic necrotizing lymphadenitis. Three weeks later, she returns with a one-week history of an intensely painful, widespread blistering rash with epidermal detachment (positive Nikolsky sign), sparing photoprotected areas. DIF reveals C3 and IgM deposition along the basement membrane. What’s Your Diagnosis?

March 31, 2025

A 57-year-old man with a one-year history of progressive proximal interphalangeal joint flexion contracture undergoes successful open fasciectomy. Six months later, he reports intermittent pallor in his left little finger after cold exposure, resolving with rewarming. Digital Allen’s test shows sluggish ulnar digital artery circulation. What’s your diagnosis?

March 24, 2025

A 57-year-old man presents with a painless swelling in the thenar region of the hand that has gradually enlarged over two years. He has a phenotype characterized by red hair, freckles, pale skin, and extensive outdoor work without sunscreen use. The mass, measuring approximately 2 cm, is solid, non-tender, and mobile, with no impairment of hand function. Imaging reveals a well-defined, heterogeneous lesion with pseudo-capsule rupture and infiltration of the thenar eminence muscle. Biopsy results show a poorly differentiated neoplasm positive for HMB45, S100. What’s your diagnosis?

March 17, 2025

A 71-year-old male presents with a large, painless, slow-growing mass on the left upper lip, persisting for six months. Clinical examination reveals a well-circumscribed, sessile, smooth-surfaced submucosal lesion with a yellowish appearance and tense-elastic consistency. He has no history of smoking, alcohol use, systemic diseases, surgery, or recurrent mouth ulcers. Ultrasound confirms a hypoechoic, gelatinous mass, and Doppler imaging excludes high-flow vascular involvement. What’s Your Diagnosis?

March 10, 2025

A 19-year-old female presents with a urinary tract infection and is incidentally found to have anemia and mucocutaneous pigmentation on the lips, oral cavity, palms, and soles, present since birth. She reports occasional rectal bleeding and intermittent abdominal pain, but denies significant weight loss or significant family history. What’s Your Diagnosis?

March 03, 2025

3-year-old girl presented with weakness and inability to use her left lower limb after receiving a DPT vaccine. She could not walk and had difficulty with dorsiflexion of the left foot. A nerve conduction test revealed which of the following?

February 24, 2025

A 34-year-old male with discolored yellowish-brown posterior teeth requests bleaching treatment. Intraoral exams reveal premolars and molars are affected, showing yellowish-brown banding. He recalls multiple childhood respiratory infections but does not remember his medication from then. What’s your diagnosis?

February 17, 2025

17-year-old female presented with unilateral, painful swelling on the dorsum of her right hand, which appeared over 20 days without trauma or other symptoms. Clinical and radiological exams were unremarkable, but the swelling resolved spontaneously after five days. Psychiatric evaluation revealed borderline personality traits and extensive medical knowledge. What's Your Diagnosis?