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A 71-year-old woman with primary cold agglutinin disease (CAD) was successfully treated with the glucocorticoid prednisone, a case study reported.
Its scientists noted that primary CAD typically does not respond to glucocorticoids, but in particular instances like this case, it can.
The study, “A Case of Idiopathic Cold Agglutinin Hemolytic Anemia Successfully Treated With Steroids,” was published in the journal Cureus.
In CAD, autoantibodies known as cold agglutinins bind to red blood cells at low temperatures, causing them to clump together and die in a process called hemolysis.
While in primary CAD the cause of the disease is unknown, secondary CAD is associated with an underlying illness, such as an infection, another autoimmune disorder, or some types of cancer.