AR-467947: A GPR119 Agonist with Durable Reduction of Post-Prandialand Fasted Blood Glucose in a Model of Type 2 Diabetes


Abstract

Array Array GPR119 agonists provide enhanced glucose control in combination with metformin and sitagliptinagonists provide enhanced glucose control in combination with metformin and sitagliptin. AR-467947, an early lead compound, showed high oral bioavailability across species. AR-467947 demonstrated on-target mechanism of action with increased GLP-1 secretion as a single agent.
Poster
non-peer-reviewed

AR-467947: A GPR119 Agonist with Durable Reduction of Post-Prandialand Fasted Blood Glucose in a Model of Type 2 Diabetes


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