Acetaminophen/ Hydrocodone 10-325 mg is a painkiller and fever reducer commonly prescribed to patients. Narcotic analgesics, of which Hydrocodone 10-325 is a member, are a class of medications (pain medicines). As a result, it relieves or inhibits coughing by acting on the CNS. The combination of Hydrocodone and acetaminophen is used to relieve pain that is severe enough to need the use of an opioid and when other pain medications have not worked or have been tolerated well enough. Taking Hydrocodone alters your body’s response to pain in the brain.